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176 The remaining cysteine circulates mostly as cystine (2530%, 4050 M) and the low abundance pool constituted by reduced cysteine

An in vitro study of IS on mesangial cells revealed that exposure of cells to IS at the concentrations seen in CKD patients would increase intracellular superoxide, hydrogen peroxide, and peroxyl radical generation through NOX activation, and lead to mesangial cell toxicity

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